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KMID : 0043319850080010031
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Archives of Pharmacal Research
1985 Volume.8 No. 1 p.31 ~ p.38
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Effects of Antitumor Polysaccharides from Forsythia Corea on the Immune Function (I)
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Moon CK
Park KS/Lee SH/Ha BJ/Lee BG
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Abstract
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Polysaccharide fractions were prepared from Forsythia Corea by several different extraction schedules. The fractions obtained were designated as ForCo A, ForCo B and ForCo C respectively. ForCo C was further purified through Sephadex G 200 column chromatography and obtained two subfractions (Coreana A, Coreana B). ForCo C showed marked antitumor activity against sarcoma 180 and its activity was dose-dependent. Coreana A, purified from ForCo C, showed somewhat higher antitumor activity. ForCo C increased the number of circulating leucocytes and peritoneal exudate cells, but didn’’t show any significant effects on the phagocytic activity and total serum protein level. Chemical analysis showed that ForCo C was composed of glucose, galactose, xylose and arabinose. A close relationship between antitumor activities and polysaccharide contents was observed. These results indicate strongly that antitumor active principle of Forsythia Corea is polysaccharide.
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KEYWORD
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